Methods for improving sensitivity and specificity of screening a

Details Methods for improving sensitivity and specificity of screening a Methods for improving sensitivity and specificity of screening a

1999-03-26

2000-11-07

Sisson, Bradley L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 6, 435 911, 435 723, 436 94, 536 231, C12P 1934, C12Q 168, G01N 33574, G01N 3300, C07H 2102

Patent

active

061435295

ABSTRACT:
Methods of the invention comprise assays for markers indicative of cancer or precancer. Assays of the invention are performed on samples obtained from a patient by non-invasive or minimally-invasive methods. The invention provides nucleic acid indicia of cancer or precancer with high sensitivities and high specificities for detection.

REFERENCES:
Mulcahy et al., A prospective study of K-ras mutations in the plasma of pancreatic cancer patients. Clin. Cancer Res. 4, 271-275, Feb. 1998.
Sidransky et al., Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. Science 256, 102-105, 1992.

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