Therapeutic compositions and methods and diagnostic assays for t

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...

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435 721, 436501, 436504, 53038824, 5303892, 5303913, G01N 3368, G01N 33566, C07K 1618

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061434914

ABSTRACT:
Method and compositions for treating type II diabetes; and type II diabetes diagnostics are disclosed

REFERENCES:
patent: 5800998 (1999-09-01), Glucksmann
Angel, I. et al. "Normalization of Insulin Secretion by a Selective .alpha.2-Adrenoceptor Antagonist Restores GLUT-4 Glucose Transporter Expression in Adipose Tissue of Type II Diabetic Rats", Endocrinology, 137(5): 2022-2027 (1995).
Bach, I. and Yaniv, M., "More Potent Transcriptional Activators or a Transdominant inhibitor of the HNF1 Homeoprotein Family are Generated by Alternative RNA Processing", EMBO J., 11(12): 4229-4242 (and corrigendum), (1993).
Barrera-Hernandez, G. et al., "Effects of Diabetes Mellitus on Hepatocyte Nuclear Factor 1 Decrease Albumin Gene Transcription", J. Biol. Chem., 17(271): 9969-9975 (1996).
Baumhueter, S. et al., "HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF", Genes & Devel., 4(3): 372-379 (1990).
Beck-Nielsen, H. et al., "Insulin Action and Insulin Secretion in Identical Twins with MODY", Diabetes, 37: 730-735 (1988).
Boutin, P.et al., An Automated Flourescent Single-Strand Conformation Polymorphism Technique for Screening Mutations in the Hepatocyte Nuclear Factor 1 Gene (Maturity-Onset Diabetes of the Young), Diabetes, 46: 2108-2109 (1997).
Braithwaite, S. et al., "Reduced Expression of Hexokinase II in Insulin-Resistant Diabetes", Diabetes, 44: 43-48 (1995).
Byrne, M. et al., "Altered Insulin Secretory Responses to Glucose in Diabetic and Nondiabetic Subjects with Mutations in the Diabetes Susceptibility Gene MODY3 on Chromosome 12", Diabetes, 45: 1503-1510 (1996).
Byrne, M. et al., "Altered Insulin Secretory Responses to Glucose in Subjects with a Mutation in the MODY1 Gene on Chromosome 20", Diabetes, 44: 699-704 (1995).
Cereghini, S. et al. "Hepatocyte Differentiation and Extinction is Accompanied by a Block in the Synthesis of mRNA Coding for the Transcription Factor HNF1/LFB1", EMBO J., 9(7): 2257-2263 (1990).
Costa, R. et al., "Similarities in thransthyretin gene expression and differences in transcription factors: Liver and yolk sac compared to choroid plexus", Proc. Nat. Acad. Sci., 87: 6589-6593 (1990).
Costa, R. et al., "Multiple hepatocyte-enriched nuclear factors function in alph1a1-antitrypsin genes", Mol. Cell. Biol., 9(4): 1415-1424 (1989).
Costa, R. et al., "A liver-specific DNA-inding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha1-antitrysin, albumin, and simian virus 40 genes", Proc Nat. Acad. Sci., 85: 3840-3844 (1988).
Drewes, T. et al., "Human Hepatocyte Nuclear Factor 4 Isoforms are Encoded by Distinct and Differently Expressed Genes", Mol. Cell. Biol., 3(16): 925-931 (1996).
Fajan, S. et al., "Maturity-Onset Diabetes of the Young", Life Sciences, 6(55): 413-422 (1994).
Glucksmann, A. et al., "Novel Mutations and a Mutational Hotspot in the MODY3 Gene", Diabetes, 46: 1081-1086 (1997).
Horikawa, Y., "Mutation in hepatocyte nuclear factor 1b gene (TCF2) associated with MODY", Nature Genetics, 17: 384-385 (1997).
Kaisaki, P. et al., "Mutations in the Hepatocyte Nuclear Facotr-1a Gene in MODY and Early-Onset NIDDM", Diabetes, 46: 528-535 (1997).
Lai, E. et al., "HNF-3A, a hepatocyte-enriched transcription factor of a novel structure is regulated transcriptionally", Genes & Devel., 4(8): 1427-1436 (1990).
Leff, T. et al., "A regulatory element in the apoCIII promoter that directs hepatic specific transcription binds to proteins in expressing and nonexpressing cell types", J. Biol. Chem., 264(27): 16132-16137 (1989).
Lesage, S. et al., Linkage Analyses of the MODY3 Locus on Chromosome 12q with Late-Onset NIDDM, Diabetes, 44: 1243-1247 (1995).
Monaci, P. et al., "Two different liver-specific factors stimulate in vitro transcription from the human alpha1-antitrypsin promoter", EMBO J., 7(7): 2075-2087 (1988).
Ringeisen, F. et al., "The Transactivation Potential of Variant Hepatocyte Nuclear Factor 1 is Modified by Alternative Splicing", J. Biol. Chem., 34(268): 25706-25711 (1992).
Sladek, F. et al., "Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily", Genes & Devel., 4(128): 2353-2365 (1990).
Stoffel, M. et al., "A Yeast Artificial Chromosome-Based Map of the Region of Chromosome 20 Containing the Diabetes-Susceptibility Gene, MODY1, and a Myeloid Leukemia Related Gene", Proc. Natl. Acad. Sci., USA, 93: 3937-3941 (1996).
Urhammer, S. et al., "Genetic variation in the hepatocyte nuclear factor-60 gene in Danish Caucasians with late-onset NIDDM", Diabetologia, 40: 473-475 (1997).
Vaxillaire, M. et al., "Search for a Third Susceptibility Gene for Maturity-Onset Diabetes of the Young", Diabetes, 43: 389-393 (1994).
Vaxillaire, M. et al. "A Gene for Maturity Onset Diabetes of the Young (MODY) Maps to Chromosome 12q", Nature Genetics, 9: 418-423 (1995).
Vaxillaire, M. et al., "Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3)", Human Mol. Genet., 6(4): 583-586 (1997).
Velho, G. and Froguel, P., "Maturing Onset Diabetes of the Young (MODY), MODY Genes and Non-Insulin Dependent Diabetes Mellitus", Diabetes & Metabolism (Paris), 23: 34-37, (1997).
Xanthopoulos, K. et al., "The different tissue transcription patterns of genes for HNF-1, C/EBP. HNF-3, and HNF-4, protein factors that govern liver-specific transcription", Proc Nat. Acad. Sci., 88: 3807-3811 (1991).
Yamada, S. et al., "Mutations in the Hepatocyte Nuclear Factor .alpha. Gene (MODY3) Are Not a Major Cause of Late-Onset NIDDM in Japanese Subjects", Diabetes, 46: 1512-1513 (1997).
Yamagata, K. et al., "Mutations in the Hepatocyte Nuclear Factor-1.alpha. Gene in Maturity-Onset Diabetes of the Young (MODY3)", Nature, 384: 455-458 (1996).
Yamagata, K. et al., "Mutations in the Hepatocyte Nuclear Factor-4.alpha. Gene in Maturity-Onset Diabetes of the Young (MODY1)", Nature, 384: 458-460 (1996).
Zhong, W. et al., "Tissue-Specific Regulation of Mouse Hepatocyte Nuclear Factor 4 Expression" Mol. Cell. Bio., 11(14): 7276-7284 (1994).
International Search Report for International Application No. PCT/US 97/20532.
International Search Report for International Application No. PCT/US 91/09733.
Webster's II New Riverside Dictionary. The Riverside Publishing Co., p. 687 (1994).

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