Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1999-03-08
2000-11-07
Spear, James M.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424484, 424469, 424457, 424486, A61K 914, A61K 926, A61K 952
Patent
active
061433284
ABSTRACT:
Sustained release pharmaceutical formulations containing morphine, or a pharmaceutically acceptable salt thereof, as active ingredient, suitable for administration on a once daily basis, are disclosed. In a first aspect, an orally administrable sustained release unit dosage form gives a peak plasma level at 1.0 to 6 hours after administration. In a second aspect, the formulation provides a W.sub.50 for the M-6-G metabolite for morphine of between 4 and 12 hours. A third aspect concerns the pharmaceutical unit dosage form obtained by compressing multiparticulates comprising a pharmaceutically active substance in a matrix of hydrophobic fusible material having a melting point of from 35 to 150.degree. C.
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Thomsen,
Heafield Joanne
Knott Trevor John
Leslie Stewart Thomas
Malkowska Sandra Therese Antoinette
Miller Ronald Brown
Euro-Celtique S.A.
Spear James M.
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