Methods for treating pancreatic disorders

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4242391, A61K 3902, A61K 3908

Patent

active

061433063

ABSTRACT:
A method for treating a pancreatic disorder by local administration of a neurotoxin, such as a botulinum toxin, into a cholinergic influenced, exocrine pancreas or endocrine pancreas, thereby reducing a secretion from the injected pancreatic tissue and effectively treating the pancreatic disorder.

REFERENCES:
patent: 5437291 (1995-08-01), Pasricha et al.
patent: 5674205 (1997-10-01), Pasricha et al.
Ahren, B., et al.; Increased Insulin Secretion and Normalization of Glucose Tolerance by Cholinergic Agonism in High Fat-Fed Mice; Am. J. Physiol. 277 (Endocrinol. Metab. 40): E93-E102; (1999).
.ANG.kesson, B., et al.; Influence of Nitric Oxide Modulators on Cholinergically Stimulated Hormone Release from Mouse Islets; Journal of Physiology (1999); 515.2, pp. 463-473.
Beger, H.G., et al. (Editors); The Pancreas vol. 1 (1998); Blackwell Science Ltd.; pp. 64-67, 83-84, 109-110, and 720.
Beglinger, C.; Relevant Aspects of Physiology in Chronic Pancreatitis; Dig. Dis. (1992); 10:326-329.
Bilchik, A., et al.; Amelioration of Cholinergic-Induced Pancreatitis with a Selective Cholecystokinin Receptor Antagonist; Arch. Surg. (Dec. 1990); vol. 125, 1546-1549.
Boyd, R.S., et al.; The Effect of Botulinum Neurotoxin-B on Insulin Release from a B-Cell Line; Movement Disorders (1995); vol. 10, No. 3; Item 19; 376.
Boyd, R.S., et al.; The Insulin Secreting B-Cell Line HIT-15 Contains SNAP-25 Which is a Target for Botulinum Neurotoxin-A; Movement Disorders (1995); vol. 10, No. 3; Item 20; 376.
Brunicardi, F.C., et al., Selective Neurohormonal Interactions in Islet Cell Secretion in the Isolated Perfused Human Pancreas, Journal of Surgical Research (1990);48, 273-278.
Czako, L., et al.; Pancreatic Fluid Hypersecretion in Rats After Acute Pancreatitis; Digestive Diseases and Sciences (Feb. 1997); vol. 42, No. 2; 265-272.
Dressel, T.D., et al.; The Effect of Atropine and Duct Decompression on the Evolution of Diazinon.RTM.-Induced Acute Canine Pancreatiti; Ann. Surg. (Apr. 1982); vol. 195:4; 424-434.
Fauci, A.S., et al. (Editors); Harrison's Principles of Internal Medicine, 14.sup.th Edition (1998); McGraw-Hill; 2064-2065.
Gonelle-Gispert, C., et al.; SNAP-25A AND-25B Isoforms are Both Expressed in Insulin-Secreting Cells and Can Function in Insulin Secretion; Biochem. J. (1999); 339:159-165.
Gronroos, J.M., et al.; Alcohol, Pancreatic Muscarinic Receptors and Acute Pancreatitis; Exp Toxic Pathol (1994); 45: 503-505.
Gronroos, J.M., et al.; Cholinergic Hypothesis of Alcoholic Pancreatitis; Dig Dis (1992); 10(1):38-45.
Kaneto, A., et al.; Effects of Vagal Stimulation on Glucagon and Insulin Secretion; Endo (1974); vol. 95, No. 4, 1005-1010.
Kohnert, K.D., et al.; Islet Neuronal Abnormalities Associated with Impaired Insulin Secretion in Type 2 Diabetes in the Chinese Hamster; Regulatory Peptides 82 (1999); 71-79.
Laskawi, R., et al.; Up-to-Date Report of Botulinum Toxin Type A Treatment in Patients with Gustatory Sweating (Frey's Syndrome); Laryngoscope 108 (Mar. 1998); 381-384.
Ragona, R.M., et al.; Management of Parotid Sialocele with Botulinum Toxin; Laryngoscope 109 (Aug. 1999); 1344-1346.
Samuel, I., et al.; Bile-Pancreatic Juice Replacement Not Cholinergic- and Cholecystokinin-Receptor Blockade Reverses Acinar Cell Hyperstimulation After Bile-Pancreatic Duct Ligation; The American Journal of Surgery (Jan. 1996); 171(1), 207-211.
Wehrmann, T., et al.; Endoscopic Botulinum Toxin Injection into the Minor Papilla for Treatment of Idiopathic Recurrent Pancreatitis in Patients with Pancreas Divisum; Gastrointestinal Endoscopy (1999); vol. 50, No. 4, 545-548.
Zawalich, W.S., et al.; Time-Dependent Effects of Cholinergic Stimulation on Beta Cell Responsiveness; Eur J Physiol (1996); 432:589-596.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for treating pancreatic disorders does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for treating pancreatic disorders, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for treating pancreatic disorders will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1638139

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.