Enhanced yield of podophyllotoxin from natural products through

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

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A61K 3578

Patent

active

061433047

ABSTRACT:
Enhanced recovery of podophyllotoxin from biological sources is achieved through disruption or permeabilization of the physical integrity of cells and tissues in the presence of sufficient moisture so as to allow endogenous enzymes to convert podophyllotoxin glucosides to podophyllotoxin. Extraction of the podophyllotoxin from the plant material is then achieved by use of an organic solvent. Podophyllotoxin is used as an intermediate in the production of the antitumor agent etoposide and its analogues.

REFERENCES:
patent: 4788216 (1988-11-01), Leander et al.
patent: 5057616 (1991-10-01), Jennings et al.
patent: 5336605 (1994-08-01), Sakata et al.

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