Amino-substituted oxazole, oxadiazole and isoxazole-substituted

Details Amino-substituted oxazole, oxadiazole and isoxazole-substituted Amino-substituted oxazole, oxadiazole and isoxazole-substituted

1981-10-02

1983-06-14

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 22, 544 28, 548133, 548246, 548233, A61K 31545, C07D50146

Patent

active

043883168

ABSTRACT:
Broad spectrum cephalosporin antibiotics represented by the formula, ##STR1## pharmaceutical compositions of the antibiotics, and a method for treating infections are provided. In the formula, R is 2-aminooxazol-4-yl, 5-amino-1,2,4-oxadiazol-3-yl or 5-aminoisoxazol-3-yl; R' is eg. C.sub.1 -C.sub.4 alkyl; R.sub.1 is H, NH.sub.2, chloro, C.sub.1 -C.sub.4 NH--, (C.sub.1 -C.sub.4).sub.2 N--, etc. The antibiotics are best prepared by reacting a pyrazine with a 3-iodomethyl cephalosporin.

REFERENCES:
patent: 3960849 (1976-06-01), Breuer
patent: 4024133 (1977-05-01), Cook et al.
patent: 4200575 (1980-04-01), Numata et al.
patent: 4258041 (1981-03-01), O'Callaghan et al.
patent: 4278671 (1981-07-01), Ochiai et al.
Derwent Abstract 32890.

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