Process for the preparation of 2-substituted-1,4-dihydropyridine

Details Process for the preparation of 2-substituted-1,4-dihydropyridine Process for the preparation of 2-substituted-1,4-dihydropyridine

1986-11-19

1988-02-02

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546165, 546112, 546183, 546272, 546273, 546278, 546281, 546321, 546322, 544 61, 544 60, 544127, 544128, 544124, 544360, 544362, 544363, C07D21184, C07D47104, C07D41700, C07D41300

Patent

active

047230142

ABSTRACT:
The present invention provides a process for preparing a 2-substituted-1,4-dihydropyridine by providing a regiospecific bromine containing intermediate which is then reacted with a nucleophile to provide a wide range of substituents at the 2-position of 1,4-dihydropyridines. Also the present invention is novel 3-substituted-1,4-dihydropyridines having cardiovascular activity.

REFERENCES:
patent: 4567268 (1986-01-01), Young

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