N-oxide prodrug derivatives of 3-hydroxy morphinans and partial

Details N-oxide prodrug derivatives of 3-hydroxy morphinans and partial N-oxide prodrug derivatives of 3-hydroxy morphinans and partial

1985-12-02

1988-02-02

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144, C07D22122, C07D22128

Patent

active

047229284

ABSTRACT:
N-oxide prodrug derivatives of 3-hydroxy morphinan and partial morphinan analgesics, agonist-antagonists, and narcotic antagonists are useful therapeutic entities which provide enhanced bioavailability of 3-hydroxy morphinans and partial morphinans from orally administered dosage forms.

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