Prostaglandins

Details Prostaglandins Prostaglandins

1982-09-30

1984-07-03

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

546290, 546293, 546301, 560 17, 560 51, 560 53, 560 60, 560 61, 560120, 562427, 562462, 562466, 564 98, 564 99, C07C 5726, C07C 69608

Patent

active

044580916

ABSTRACT:
Novel bicyclo [2,2,1] heptanes and hept-2Z-enes are substituted at the 5-position by a 6-carboxyhex-2-enyl group or a modification thereof, and at the 6-position by an aldoxime or ketoxime group which is O-substituted by an aliphatic hydrocarbon residue, an aromatic residue, or an aliphatic hydrocarbon residue substituted directly or through an oxygen or sulphur atom by an aromatic residue. Such compounds may be prepared by the action of an oximating agent on an intermediate which is substituted at the 6-position by an aldehydic or ketonic carbonyl group. The compounds are of value for use in pharmaceutical compositions particularly in the context of the inhibition of thromboxane activity.

REFERENCES:
patent: 3946065 (1978-02-01), Matsui
patent: 4073933 (1976-03-01), Shimomura

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