Aryl and heteroaryl (phosphinylmethyl)phosphonate squalene synth

Details Aryl and heteroaryl (phosphinylmethyl)phosphonate squalene synth Aryl and heteroaryl (phosphinylmethyl)phosphonate squalene synth

1992-05-18

1994-01-11

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

558155, 558156, 562 21, A61K 3166, C07F 940

Patent

active

052781534

ABSTRACT:
Phosphonic acid squalene synthetase inhibitors are provided which are effective in lowering serum cholesterol and have the formula ##STR1## wherein m is 0 to 3, n is 1 to 5, Y.sup.1 and Y.sup.2 are H or halogen, R.sup.2, R.sup.3 and R.sup.4 are H, metal ion, C.sub.1 to C.sub.8 alkyl, C.sub.3 to C.sub.12 alkenyl, or prodrug ester, and R.sup.1 is a substituted or unsubstituted heteroaryl group or a substituted phenyl group.

REFERENCES:
patent: 4871721 (1989-10-01), Biller

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