Process for the preparation of 2-(thienyl-2)-and 2-(thienyl-3)-e

Details Process for the preparation of 2-(thienyl-2)-and 2-(thienyl-3)-e Process for the preparation of 2-(thienyl-2)-and 2-(thienyl-3)-e

1982-06-29

1984-07-03

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 59, 549 60, 549 61, 549 65, 549 68, 546284, C07D33300

Patent

active

044580860

ABSTRACT:
The present invention provides a process for the preparation of 2-(thienyl-2)- and 2-(thienyl-3)-ethylamines of the general formula: ##STR1## in which R.sub.1, which is in the 2-, 3-, 4- or 5-position, is a hydrogen atom, a straight-chained or branched alkyl radical or a heterocyclic or non-heterocyclic aromatic radical, which is optionally mono- or polysubstituted, or R.sub.1 is an alkoxy radical, a halogen atom or a nitro, carboxyl, cyano or amino group; the aminoethyl chain is in the 2- or 3-position of the thiophene nucleus; R.sub.2 is a hydrogen atom or a straight-chained or branched alkyl radical or a heterocyclic or non-heterocyclic aromatic radical, which is optionally mono- or poly-substituted; and Ar is a heterocyclic or non-heterocyclic aromatic radical, which is optionally mono- or poly-substituted.

REFERENCES:
Gilsdorf, "J. Org. Chem.", 15, 807-811 (1950).

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