Surgery – Respiratory method or device – Ozone or ion generation
Patent
1977-01-28
1977-11-29
Medbery, Aldrich F.
Surgery
Respiratory method or device
Ozone or ion generation
428 28, 128268, A61M 3100
Patent
active
040600840
ABSTRACT:
Method and therapeutic system in the form of a bandage for providing chemotherapy transdermally by administering certain drugs to unbroken skin in an initial priming dose that quickly brings the systemic concentration of drug to a therapeutic level, followed by a substantially constant dosage that holds said level. The bandage is a four-layer laminate of, from the top: a protective backing; a drug reservoir lamina that is the source of the constant dosage; a microporous membrane that controls the constant dosage rate; and an adhesive layer that is the source of the priming dose and the means by which the bandage is attached to the skin.
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patent: 3632740 (1972-01-01), Robinson et al.
patent: 3731683 (1973-05-01), Zaffaroni
patent: 3767786 (1973-10-01), MacMillan
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patent: 3849238 (1974-11-01), Gould
patent: 3993073 (1976-11-01), Zaffaroni
patent: 3996934 (1976-12-01), Zaffaroni
"Scopolamine Permeation Through Skin en Vitro", S. K. Chandrasekaran, A. S. Michaels, P. S. Campbell & J. E. Shaw, Journal Amer. Aust. Chem. Engr., , vol. 22, No. 5, pp. 828-832, Sept. 1976.
Clinical Pharmacology & Therapeutics, vol. 11, No. 5, Sept.-Oct. 1970, pp. 621-629, "A Theory of Motion Sickness Based On Pharmacological Reactions".
Drug Permeation Through Human Skin:, 37 Theory & in Vitro Experimental Measurement", Am. Inst. of Chem. Engr. Journal, vol. 21, No. 5, Authors: A. Michaels, A. Chandreaskaran, & J. E. Shaw, pp. 985-939, Sept. 1975.
Chandrasekaran Santosh Kumar
Shaw Jane Elizabeth
Urquhart John
ALZA Corporation
Ciotti Thomas E.
Mandell Edward L.
Medbery Aldrich F.
Sabatine Paul L.
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