Preparation of liposome and lipid complex compositions

Details Preparation of liposome and lipid complex compositions Preparation of liposome and lipid complex compositions

1991-08-08

1994-01-11

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424484, 264 41, 264 43, 264 47, 436829, A61K 3722, A61K 4300, B01J 1302, B01J 1318

Patent

active

052779149

ABSTRACT:
Liposome and lipidic particle formulations of compounds are prepared by dissolving in a solution of liposome-forming lipids in an aprotic solvent such as DMSO, optionally containing a lipid-solubilizing amount of a lower alkanol, and either injecting the resulting solution into an aqueous solution, or the aqueous solution into the resulting solution. The resulting liposome or lipidic particle suspension may then be dialyzed or otherwise concentrated. This method is particularly useful for compounds which are poorly-soluble in aqueous solution, but is generally useful for any compound or combination of compounds which can be dissolved in the aprotic solvent or aprotic solvent/lower alkanol mixture.

REFERENCES:
patent: 4508703 (1985-04-01), Redziniak et al.
patent: 4619913 (1986-10-01), Luck et al.
patent: 4812312 (1989-03-01), Lopez-Berestein et al.
patent: 4839175 (1989-06-01), Guo et al.
patent: 5077057 (1991-12-01), Szoka, Jr.
F. C. Szoka et al, Antimicrob Agents Chemother (1987) 31:421-429.

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