Clay enclosed transition and rare earth metal ions as contrast a

Details Clay enclosed transition and rare earth metal ions as contrast a Clay enclosed transition and rare earth metal ions as contrast a

1992-06-15

1994-01-11

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 4, 436173, 1286534, 514836, 514964, G01N 2408

Patent

active

052778967

ABSTRACT:
The invention relates to compositions and methods of using clay-enclosed paramagnetic ions as image brightening or image contrast agents. In particular, T.sub.1 relaxivity measurements on Hectorite and mortmorillonite clay-enclosed trivalent gadolinium suggest improved imaging over zeolite-enclosed paramagnetic species. Clay-enclosed gadolinium complexes are amenable to convenient administration in oral preparations and are readily formulated in stable aqueous suspensions. Other transition metal ions, including divalent manganese, may be enclosed in the clay structures, either as free metals or in the forms of chelated complexes. Alternatively, improved relaxivities are envisioned for clays incorporating a paramagnetic metal ion as part of the framework structure.

REFERENCES:
patent: 4388285 (1983-06-01), Rankel et al.
patent: 4728892 (1988-03-01), Vinegar et al.
patent: 4927624 (1990-05-01), Bryant et al.
patent: 5122363 (1992-06-01), Balkus, Jr. et al.
Article in German by Claussen et al., "Orale Kontrastmittel fur die magnetische Resonanztomographie des Abdomens. Teil III: Erste Patientenuntersuchungen mit Gadolinium-DTPA", RoFo, vol. 148, pp. 683-689, 1989.
Article by Braybrook and Hall, "Effect of pH on the Nuclear Magnetic Resonance Relaxivity of Encapsulated Solid Paramagnetic Substances", Drug Design and Delivery, vol. 4, pp. 93-95, 1989.
Article by Denkewicz, "Zeolite Science: An Overview", Journal of Materials Education, vol. 9, No. 5, pp. 519-564, 1987.
Article by Hahn et al., "First Clinical Trial of a New Superparamagnetic Iron Oxide for Use As an Oral Gastrointestinal Contrast Agent in MR Imaging", Radiology, vol. 175, pp. 695-700, 1990.
The Condensed Chemical Dictionary (1971) p. 190.
Atlas of Zeolite Structures (1987) p. 344.

Affiliated with

Also associated with

Rating

Clay enclosed transition and rare earth metal ions as contrast a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Clay enclosed transition and rare earth metal ions as contrast a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Clay enclosed transition and rare earth metal ions as contrast a will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1629431