Whitening cosmetic composition

Details Whitening cosmetic composition Whitening cosmetic composition

1992-12-03

1994-05-31

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

424 63, A61K 600

Patent

active

053167678

ABSTRACT:
Disclosed is a whitening cosmetic composition comprising .gamma.-L-glutamyl-L-cystine, .gamma.-L-glutamyl-L-cysteine disulfide, oxidized glutathione or a derivative thereof, the amino group of which is acylated with an alkanoyl group or an aroyl group. The whitening cosmetic composition of the present invention have extremely good in water solubility and heat stability and stability during storage and show a melanin formation inhibitory activity against melanoma cells without any cytotoxicity.

REFERENCES:
patent: 4419343 (1983-12-01), Pauly
patent: 4812307 (1989-03-01), Siuta-Mangano
patent: 4927808 (1990-05-01), Kitahara et al.
patent: 4959393 (1990-09-01), Torihara et al.
patent: 4990330 (1991-02-01), Oyama
European Search Report for corresponding application EP 91308743.3, issued Feb. 17, 1992.
Anderson, M. E. et al., Proc. Natl. Acad. Sci. USA 80:707-711 (1983).
Meister, A. et al., Ann. Rev. Biochem. 52:711-713 (1983).
Anderson, M. E. et al., Meth. Enzymol. 113:555-564 (1985).
Reitman, J. S. et al., Biochim. Ciophys. acta 208:159-162 (1970).

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