Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1993-01-28
1994-05-31
Hill, Jr., Robert J.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
424 9, 435 71, 435 79, 435 3, 435 4, 435 30, 4352402, 530350, 530380, 530395, 530397, 530398, 530399, C07K 300, C12Q 100, A01N 3752, A61K 31155
Patent
active
053167546
ABSTRACT:
The present invention relates to a method and associated agents for measuring the presence and amount of advanced glycosylation endproducts in cells and fluids. The methods take advantage of the existence of receptors and receptor complexes for AGEs and include receptor-containing ligands comprising whole mesangial and other cells, mesangial cellular fragments and protein extracts therefrom. Competitive assays, sandwich assays and assays involving AGE antisera are disclosed. Numerous diagnostic applications are defined and test kits are also contemplated.
REFERENCES:
Vlassara et al. (1985) PNAS vol. 82:pp. 5588-5592.
Skolnik, E. et al, J. Exp. Med 174:931-939 (Oct., 1991).
Vlassara, H. et al, Science (Washington, D.C.) 240:1546-1548 (1988).
Esposito, C. et al. J. Exp. Med 170:1387-1407 (1989).
Schlondorf, D. J. Fed. Am. Soc. Exp. Biol. 1:272-281 (1987).
Lovett, D. H. et al., Kidney Int. 30/246-254 (1986).
Cerami Anthony
Vlassara Helen
Hill Jr. Robert J.
The Rockefeller University
Wang Gian P.
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