2-Amino-1,4-dihydropyridine derivatives

Details 2-Amino-1,4-dihydropyridine derivatives 2-Amino-1,4-dihydropyridine derivatives

1975-05-05

1976-07-27

Drezin, Norman A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602955B, 424258, 424266, C07D21532, C07D40104

Patent

active

039717909

ABSTRACT:
2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding 2-amino-1,4,5,6,7,8-hexahydro-5-oxoquinolines, which derivatives are further substituted by a carbonyl group in the 3-position and optionally substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and an amidine.

REFERENCES:
patent: 3441648 (1969-04-01), Loev et al.
patent: 3455945 (1969-07-01), Loev
patent: 3574843 (1971-04-01), Bossert et al.
patent: 3644627 (1972-02-01), Bossert et al.
patent: 3856798 (1974-12-01), Meyer et al.
patent: 3862161 (1975-01-01), Bossert et al.

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