Cephalosporins having (.alpha.-etherified oximino)acylamido grou

Details Cephalosporins having (.alpha.-etherified oximino)acylamido grou Cephalosporins having (.alpha.-etherified oximino)acylamido grou

1972-11-07

1976-07-27

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50120

Patent

active

039717780

ABSTRACT:
The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof characterized in that the acylamido group has the structure ##EQU1## where R is a hydrogen atom or an organic group and R.sup.a is an etherifying monovalent organic group linked to the oxygen atom through a carbon atom. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range or gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

REFERENCES:
patent: 3546219 (1970-12-01), Long et al.
patent: 3573294 (1971-03-01), Long et al.

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