Use of beta HCG for the control of retroviral infection

Details Use of beta HCG for the control of retroviral infection Use of beta HCG for the control of retroviral infection

1995-08-22

1998-09-22

O'Sullivan, Peter

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530398, A61K 3816, C07K 1459

Patent

active

058113908

ABSTRACT:
Described is a method for inhibiting the growth and/or replication of human immunodeficiency virus (HIV) in human patients. The invention relates to the unexpected activity of human chorionic gonadotropin (hCG) and in particular, to the beta chain of hCG (beta hCG) in controlling a human immunodeficiency virus (HIV) infection and other virus-related immunodeficiency disorders. The invention comprises administering an anti-HIV effective amount of beta hCG to an asymptomatic individual with an HIV infection, including an individual presenting the symptoms of AIDS.

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de Medeiros, "Distribution of the .beta.-core HCG Fragment . . . " J. Endocrin. (1992) 135:175-188.
Bourinbaiar, "Rational Problems . . . " In Andrieu, Cell Activation . . . Plenum Press 1995 pp. 71-89.
McNamee," .beta.-LCG Inhibits Kaposi's Salcoma" The Lancet v345 p. 1169 (1995).
Birnbaumer, "Hormone Action" Methods in Enzymology v109 pp. 736-749 (1985).
Bourinbaial et al. "Inhibitory Effect of LCG on HIV-1" FEBS v309: 82-84 (Aug. 1992).
Bourinbaiar et al. "Effect of hCG on Reverse Transcripase" FEMS Microbiology Let. v96 pp. 27-30 (1992).
"Controversy: Is KS Really Caused by New HerpesVirus?" Science v268 pp. 1847-1848 Jun. 1995).
Lunardi-Iskandar et al. "Tumorigenesis and Metastasis . . . " Nature v375 pp. 64-68 (May 1995).
Bourinbaiar et al. "Anti HIV Effect of .beta.HCG in vitro" Immuno. Let. 44:13-18 (1995).

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