Method for measuring sensory irritation in vitro

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

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435 72, 435 721, 4352841, 4352871, 4352882, 4353042, 4353051, 4353052, 435968, 435975, 4352884, C12Q 102, G01N 3353, C12M 300, C12C 100

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active

058112561

ABSTRACT:
Methods for ascertaining the sensory irritation of chemicals in vitro are described. The methods include the cultivation of neuronal cells alone, with target tissue cells, and with target tissue cells and mast cells; the introduction of a chemical to be tested; and the measuring of neuronal response in the form of ion uptake or change in membrane potential. A co-culture system of neuronal and target tissue cells for performing said methods is also described.

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