Apparatus for intravenous administration of solutions of cell-fr

Liquid purification or separation – Filter – Supported – shaped or superimposed formed mediums

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2101982, 210252, 210496, 422101, 205404, 514315, 514408, B01D 1508, B01D 2905

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active

058110054

ABSTRACT:
An apparatus for intravenous administration of solutions of cell-free hemoglobin is disclosed. The apparatus includes a solution of cell-free hemoglobin in fluid connection with a housing having an inlet and an outlet through which the solution of cell-free hemoglobin flows and a nitroxide bound to a matrix is contained within the housing to alleviate oxygen toxicity to the cell-free hemoglobins.

REFERENCES:
patent: 3959287 (1976-05-01), Goldstein et al.
patent: 4001200 (1977-01-01), Bonsen et al.
patent: 4001401 (1977-01-01), Bonsen et al.
patent: 4053590 (1977-10-01), Bonsen et al.
patent: 4061736 (1977-12-01), Morris et al.
patent: 4136093 (1979-01-01), Bonhard et al.
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4336248 (1982-06-01), Bonhard et al.
patent: 4376095 (1983-03-01), Hasegawa
patent: 4377512 (1983-03-01), Ajisaka et al.
patent: 4401652 (1983-08-01), Simmonds et al.
patent: 4412989 (1983-11-01), Iwashita et al.
patent: 4473494 (1984-09-01), Tye
patent: 4473496 (1984-09-01), Scannon
patent: 4529719 (1985-07-01), Tye
patent: 4563349 (1986-01-01), Miyata et al.
patent: 4584130 (1986-04-01), Bucci et al.
patent: 4598064 (1986-07-01), Walder
patent: 4600531 (1986-07-01), Walder
patent: 4670417 (1987-06-01), Iwasaki et al.
patent: 4780210 (1988-10-01), Hsia
patent: 4822681 (1989-04-01), Schossler et al.
patent: 4826811 (1989-05-01), Sehgal et al.
patent: 4831012 (1989-05-01), Estep
patent: 4834964 (1989-05-01), Rosen
patent: 4857636 (1989-08-01), Hsia
patent: 4863717 (1989-09-01), Keana
patent: 4873191 (1989-10-01), Wagner et al.
patent: 4911929 (1990-03-01), Farmer et al.
patent: 4920194 (1990-04-01), Feller et al.
patent: 4925574 (1990-05-01), Hsia
patent: 4959305 (1990-09-01), Woodrum
patent: 5061688 (1991-10-01), Beissinger et al.
patent: 5080645 (1992-01-01), Hanig
patent: 5104641 (1992-04-01), Rosen
patent: 5114932 (1992-05-01), Runge
patent: 5149425 (1992-09-01), Mazid
patent: 5234903 (1993-08-01), Nho et al.
"Pharmacokinetic Studies in the Rat on a O-Raffinose Polymerized Human Hemoglobin"; Hsia, J.C. et al., Biomaterials Artificial Cells and Immobilization Biotechnology, 1992, V20, N2-4, P587-595.
"Molecular-Weight Determinations of O-Raffinose-Polymerized Human Hemoglobin"; Moore, G. L. et al., Biomaterials Artificial Cells and Immobilization Biotechnology, 1992, et al. V20, N2-4, P293-296.
"The Toxicity of Hemoglobin"; R.M. Winslow Edited, Hemoglobin-Based Red Blood Cell Substitutes, John Hopkins University Press, Baltimore, 1992, P136-163.
"Quality-Control of Hemoglobin-Based Blood Substitutes"; Hsia, J.C. et al., Biomaterials Artificial Cells and Artificial Organs, 1988, V16, N1-3, P105-111.
"Hemoglobin-Based Blood Substitutes: Characterization of Five Pyridoxal 5'-Phosphate Derivatives of Hemoglobin"; McGarrity, M.J. et al., Journal of Chromatography-Biomedical Applications, 1987, V419, P37-50.
"Quality-Control and Scale-Up Production of Hemoglobin-Based Substitutes--From High-Pressure Liquid Chromatography to Tangential Flow Affinity Ultafiltration"; Hsia, J. C., Biomaterials, Artificial Cells, and Artificial Organs, 1987, V15, N2, P364.
"Reduced Coronary Vasoconstrictor Activity of Hemoglobin Solutions Purified by ATP-Agarose affinity Chromatography"; Vogel, W.M. et al., Life Sciences, 1987, V41, N1, P89-93.
"ATP-Hemoglobin: Anomalous Oxygen Binding Properties"; McGarrity, M.J. et al., Journal of Chromatography-Biomedical Applications, 1987, V415, N1, P136-142.
"Isolation and Partial Characterization of Pyridoxal 5'-Phosphate Hemoglobins by High-Performance Liquid Chromatography as a Quality-Control Method for Hemoglobin-Based Blood Substitutes"; M.J. McGarrity et al., Journal of Chromatography-Biomedical Applications, 1987, V413, Jan. P53-63.
"ATP-Hemoglobin Purfication by ATP-Agarose Affinity Chromatography"; J.C. Hsia et al., Journal of Chromatography, 1986, v381, N1, P153-157.
"Cell-Free Hemoglobin Potentiates Acetylcholine-Induced Coronary Vasoconstriction in Rabbit Hearts"; R. Motterlini et al., Journal of Applied Physiology, 1993 V75, P2224-2233.
"Consequences of Chemical Modifications on the Free Radical Reactions of Human Hemoglobin"; A.I. Alayash et al., Archives of Biochemistry and Biophysics, 1992, V289, N1, Oct. P114-120.
"Biologically Active Metal-Independent Superoxide Dismutase Mimics"; JB Mitchell et al., Biochemistry, 1990, V29, P2802-2807.
"Purification of Stroma-Free Haemoglobin by ATP-Agarose Affinity Chromatography"; J.C. Hsia et al., Journal of Chromatography, 1986, V374, N1, P143-148.
"Superoxide Reaction with Nitroxides"; A. Samuni et al., Free Rad. Res Comms., 1990, V9, P241-249.
"Nitroxide-stimulated H.sub.2 O.sub.2 Decomposition by Peroxidases and Pseudoperoxidases"; R.J. Mehlhorn et al., Free Rad. Res. Comms., 1992, v17, N3, P157-175.
"Fine Tuning of Polymerized Pyridoxylated Hemoglobin as a Red Blood Cell Substitute"; J.C. Hsia, The Red cell: Seventh Ann Arbor Conference, 1989, P339-349.
"A Clinical Safety Trial of Stroma-Free Hemoglobin"; J.P. Savitsky et al., Clin. Pharmacol. Ther., 1978, V23, P73-80.
"Perspectives on Hydrogen Peroxide and Drug-Induced Hemolytic Anemia in Glucose-6-Phosphate Dehydrogenase Deficiency," P. Hochestein, Free Radical Biology & Medicine, 1988, V5, P387-392.
"Pharmacological Evidence that Endothelium-Derived Relaxing Factor is Nitric Oxide: Use of Pyrogallol and Superoxide Dismutase to Study Endothelium-Dependent and Nitric Oxide-Elixited Vascular Smooth Muscle Relaxation", L.J. Ignarro et al., Journal of Pharmacology and Experimental Therapeutics, 1988, v244, N1, P181-189.
"Superoxide Anions and Hyperoxia Inactivate Endothelium-Derived Relaxing Facor," G. M. Rubanyi et al., American Journal of Physiology, (1986), (Heart Cir. Physiol. 19): V250, PH822-H827.
"Superoxide Anion is Involved in the Breakdown of Endothelium-Derived Vascular Relaxing Factor," R. J. Gryglewski et al., Nature, (1986). V320, P454-456.
"Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide," Louis J. Ignarro, Annu. Rev. Pharmacol. Toxicol., (1990), v30, P535-560.
"Characterization of the L-Arginine:Nitric Oxide Pathway in Human Platelets," M. W. Radomski et al., Br. J. Pharmacol, (1990), V101, P325-328.
"Selective Blockade of Endothelium-Dependent and Glyceryl Trinitrate-Induced Relaxation by Hemoglobin and by Methylene Blue in the Rabbit Aorta," William Martin et al., The Journal of Pharmacology and Experimental Therapeutics, (1985), V232, N3, P708-716.
"Electron Spin Echo Studies of Hemoglobin Cyanide and Nitroxide Derivatives"; Y.V.S. Rama Krishna et al., Biochimica et Biophysica Acta, 1987, V916, P48-53.
"Physics and Chemistry of Spin Labels," H.M. McConnell, et al., Quarterly Reviews of Biophysics, 1970, v3, N1, P91-136.
"Spin Labels"; C. Hamilton et al., Structural Chemistry and Molecular Biology, A. Rich et al, eds. W. H. Freeman, San Francisco, 1968, P115-149.
"Nitroxide Free Radicals: Spin Labels for Probing Biomolecular Structure," O.H. Griffith et al., Accounts of Chemical Research, 1969, V2, N1, P17-24.
"The Spin Label Method"; I.C.P. Smith, Biological Applications of Electron Spin Resonance, H.M. Swartz, et al., eds., Wiley/Interscience, New York, 1972 P484-539.
"Relaxation of Bovine Coronary Artery and Activation of Coronary Arterial Guanylate Cyclase by Nitric Oxide, Nitroprusside and a Carcinogenic Nitrosamine," C.A. Grueter et al., Journal of Cyclic Nucleotide Research, 1979, V5, N3 P211-224.
"Detection of Free Radicals as Intermediates in the Methemoglobin Formation from Oxyhemoglobin Induced by Hydroxylamine"; Klaus Stolze et al., Biochemical Pharmacology, 1989, V38, N18, P3055-3059.
"Nitroxide-Stimulated H.sub.2 O.sub.2 Decomposition by Peroxidases and Pseudoperoxidases"; Rolf J. Mehlhorn and Christopher E. Swanson. Free Rad. Res. Comms. V17, N3, P157-175.
"Nitric Oxide, and Inhibitor of Lipid Oxidation by Lipoxygenase, Cycloosygenase, and Hemoglobin"; Joseph Kanner, Stela Harel, and Rina Granit Lipids, 1992, V27, N1, P46-49.
"Inhibition of Lipid Peroxidation by Spin Labels--Relationships Between structure and Function"; Ulf A. Nilsson, Lars-Inge Olsson, Gunnar Carlin, and Ann-Christi

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