Intermediates for 1,3-disubstituted piperidine compounds as neur

Details Intermediates for 1,3-disubstituted piperidine compounds as neur Intermediates for 1,3-disubstituted piperidine compounds as neur

1986-02-14

1986-11-18

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21122

Patent

active

046237283

ABSTRACT:
Certain novel 1-(substituted-alkyl)-3-(3-hydroxyphenyl)piperidine compounds, and the pharmeceutically-acceptable acid-addition salts thereof, possess pharmaceutical activity as neuroleptic agents, and they are useful for treating psychotic disorders, e.g. schizophrenia, in human subjects. In particular, they are useful for alleviating such symptoms as anxiety, agitation, excessive aggression, tension and social or emotional withdrawal in psychotic patients.
Certain 3-(3-methoxyphenyl)piperidine compounds are useful as chemical intermediates to the aforementioned neuroleptic agents.

REFERENCES:
patent: 4072685 (1978-02-01), Nedelec et al.
patent: 4241071 (1980-12-01), Martin et al.
patent: 4332942 (1982-06-01), Althuis et al.
Julia et al., Bulletin de la Societe Chimique de France, No. 3, pp. 1000-1007 (1968).
Hacksell et al., Journal of Medicinal Chemistry, 24, pp. 1475-1482 (1981).

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