Transplantable artificial tissue

Details Transplantable artificial tissue Transplantable artificial tissue

1987-11-06

1990-02-20

Cannon, Alan W.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

623 66, 623 12, 435178, 424 95, 424110, A61F 202

Patent

active

049022954

ABSTRACT:
A transplantable artificial tissue matrix structure containing viable cells which is suitable for insertion into the body is made by polymerizing precursors in an aqueous solution to form a shape retaining solid matrix comprising viable cells, matrix polymer and reversible gel polymer. The solution contains a matrix polymer precursor, a reversible gel polymer precursor, and viable cells. The reversible gel polymer is dissolved and removed to yield an insoluble, porous matrix containing viable cells. The conditions and reagents are selected to maintain the viability of the cells. The invention is particularly suitable for artificial transplant matrix tissue containing pancreatic islet cells.

REFERENCES:
patent: 4645669 (1987-02-01), Reid
patent: 4722898 (1988-02-01), Errede et al.
Bell et al., "Reconstruction of a Thyroid Gland Equivalent from Cells and Matrix Materials", J. Exp. Zool., 232:277-285, (1984).

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