Diffusion gradient bioreactor and extracorporeal liver device us

Details Diffusion gradient bioreactor and extracorporeal liver device us Diffusion gradient bioreactor and extracorporeal liver device us

1996-04-23

1998-10-27

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Apparatus

Bioreactor

435 12, 435289, 435370, 435375, 21050021, B01D 6300, C12N 500

Patent

active

058277293

ABSTRACT:
A tissue engineering bioreactor is disclosed for growing three-dimensional tissue. Cells are seeded onto a mesh and provided with two media flows, each contacting a different side of the cells. The media flows contain different concentrations of nutrients, allowing nutrients to be delivered to the cells by diffusion gradient. The bioreactor can be used to grow liver tissue, and designed as an extracorporeal liver assist device in which blood or plasma is exposed to the three-dimensional liver tissue. The blood or plasma from a patient directed to flow against the liver tissue. The liver tissue is further exposed on its opposite side to media providing nutrients and gases. The device provides porous boundaries between the blood or plasma, tissue, and media, allowing nutrient and protein delivery by diffusion gradient to dialyze a patient's blood.

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