Process for efficiently producing transglutaminase through DNA r

Details Process for efficiently producing transglutaminase through DNA r Process for efficiently producing transglutaminase through DNA r

1996-05-17

1998-10-27

Grimes, Eric

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 691, 43525233, 4353201, 530350, 530825, 536 232, 536 237, C12N 910, C12P 2106, C07K 100, C07H 2104

Patent

active

058277129

ABSTRACT:
The present invention relates to a process for producing a transglutaminase, which comprises incubating Escherichia coli expressing genes encoding a heat shock protein (DnaJ) and a transglutaminase. The transglutaminase is produced in large quantities, at low cost and has the appropriate stereostructure to render the transglutaminase biologically active. The transglutaminase so produced is useful in the food industry.

REFERENCES:
patent: 5420025 (1995-05-01), Takagi et al.
patent: 5514573 (1996-05-01), Yasueda et al.
Yasushi Kawata, et al., FEBS Letters, vol. 345, No. 2/03, pp. 229-232, "Chaperonin Groe and ADP Facilitate the Folding of Various Proteins and Protect Against Heat Inactivation", May 30, 1994.
Thomas Langer, et al., Nature, vol. 356, pp. 683-689, "Successive Action of DNAK, DNAJ, and Groel Along the Pathway of Chaperone-Mediated Protein Folding", Apr. 23, 1992.
Koji Ikura, et al., European Journal of Biochemistry, vol. 187, pp. 705-711, "Expression of Guinea-Pig Liver Transglutaminase CDNA in Escherichia Coli", 1990.
Ohki et al. (1986) J. Biol. Chem. 261, 1778-1781.
Lee et al. (1992) J. Biol. Chem. 267, 2849-2852.

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