Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-08-10
1998-10-27
Huff, Sheela
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435810, 435975, 435 792, 436 63, 5303871, 5303879, 5303881, G01N 3353, G01N 3348, C07K 1600, C12P 2108
Patent
active
058276688
ABSTRACT:
The assay of rheumatoid arthritis by reference to IgA-.alpha..sub.1 antitrypsin complex present in analytes is facilitated by certain novel antibody reagents. These are ligands comprising an antibody domain specific for an antigenic determinant of a complex of human IgA and .alpha..sub.1 -antitrypsin, this antibody domain being substantially non reactive with free human IgA and free human .alpha..sub.1 -antitrypsin. Monoclonal antibodies to the naturally occurring IgA-.alpha..sub.1 AT complex and monoclonal or polyclonal antibodies to a synthetic peptide are preferred. The synthetic peptide in itself part of the invention and preferably has an amino acid sequence: Val-Ser-Val-Val-Met-Ala-Glu-Val-Asp-Gly-Thr-Cys-Tyr (SEQ ID NO:2)
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Lewin Ian Victor
Nayyar Sarita
Stanworth Dennis Raymond
Eyler Yvonne
Huff Sheela
Peptide Therapeutics Limited
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