Nucleic acid ligands

Details Nucleic acid ligands Nucleic acid ligands

1995-03-24

1997-12-09

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 912, 935 77, 935 78, C07H 2102, C07H 2104, C12Q 168, C12Q 1934

Patent

active

056962495

ABSTRACT:
A new class of nucleic acid compounds, referred to as nucleic acid ligands, have been shown to exist that have a specific binding affinity for three dimensional molecular targets. In a preferred embodiment the ligands are identified by the method of the invention referred to as the Systematic Evolution of Ligands by EXponential enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched in high affinity nucleic acids and amplified for further partitioning.

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Kinzler and Vogelstein (1989) Nucleic Acids Research 17:3645.
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Levisohn and Spiegelman Proc. Natl. Acad. Sci. USA 60:866.
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Oliphant and Struhl (1988) Nucleic Acids Research 16:7673.
Oliphant and Struhl (1987) Methods in Enzymology 155:568.
Oliphant et al. (1986) Gene 44:177.
Robertson and Joyce (1990) Nature 344:467.
Thiesen and Bach (1990) Nucleic Acids Research 18:3203.
Orgel (1979) Proc. R. Soc. Lon. B205:435.
Kramer et al. (1974) J. Mole. Biol. 89:719.

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