Triazolopyrazinamines useful as adjuncts to radiation therapy

Details Triazolopyrazinamines useful as adjuncts to radiation therapy Triazolopyrazinamines useful as adjuncts to radiation therapy

1982-05-17

1984-03-20

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544409, 424250, C07D48704, A61K 31495, C07D24120

Patent

active

044382669

ABSTRACT:
8-Halo-6-nitro-1,2,4-triazolo[4,3-a]pyrazine and its corresponding 3-alkyl derivatives are prepared by converting amino-5,6-dichloropyrazinecarboxylic acid to 5-chloro-6-hydrazino-3-nitropyrazinamine and treating said hydrazino compound with a lower alkyl ortho ester of a loweraliphatic carboxylic acid to produce an 8-chloro-6-nitro-1,2,4-triazolo[4,3-a]pyrazine-5-amine or the corresponding 3-loweralkyl derivatives thereof.

REFERENCES:
patent: 3541093 (1970-11-01), Tull et al.
patent: 3629260 (1971-12-01), Maquire et al.
patent: 3660397 (1972-05-01), Jones et al.
patent: 3976644 (1976-08-01), McGregor et al.
Cragoe et al., J. Med. Chem., 10 66, (1967).

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