Method for preparation of arylpyruvic acid

Details Method for preparation of arylpyruvic acid Method for preparation of arylpyruvic acid

1982-05-24

1984-05-08

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 5110

Patent

active

044476442

ABSTRACT:
A method for the preparation of optionally substituted arylpyruvic acids by reaction of optionally substituted arylmethylhalides with carbon monoxide in the presence of a metal carbonyl compound and a base is disclosed wherein the base is an alkali metal hydroxide, the process is carried out at a temperature of -10.degree. to +70.degree. C. in the presence of an alcohol or cyclic ether.

REFERENCES:
patent: 3116306 (1963-12-01), Heck
patent: 3928429 (1975-12-01), El-Chahawi
patent: 4152352 (1979-05-01), Perron
patent: 4351952 (1982-09-01), Foa

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