Process to prepare 7-substituted cephalosporins or 6-substituted

Details Process to prepare 7-substituted cephalosporins or 6-substituted Process to prepare 7-substituted cephalosporins or 6-substituted

1977-06-03

1984-05-08

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

2602391, 544 15, 544 16, 544 22, 544 24, 544 25, 544 26, 544 27, 544 28, 544 29, 544 30, C07D50104, C07D49904

Patent

active

044476027

ABSTRACT:
A process is provided which yields derivatives of cephalosporins and penicillins. The process starts with 7-acylaminocephalosporin, or 6-acylaminopenicillin, then the latter compounds are treated with an organolithium compound, followed with t-butyl-hypochlorite. Finally, a defined reagent is added yielding a side chain on the carbon adjacent to the amino-nitrogen. Novel intermediate compounds are also described. The end compounds prepared are active against both gram-positive and gram-negative bacteria.

REFERENCES:
patent: 3994885 (1976-11-01), Koppel
patent: 4044000 (1977-08-01), Koppel

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