Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-10-16
1997-02-18
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514502, 514492, 514493, 514494, 514495, 514498, 514499, 514501, 514505, A61K 3816, A61K 31295
Patent
active
056041993
ABSTRACT:
A method of treating skeletal muscle fibrosis in mammals. The novel method is effective for reducing the extent of skeletal muscle fibrosis in an individual who suffers from a disorder which targets skeletal muscle tissue, such as Duchenne's and Becker's muscular dystrophy and denervation atrophy induced by either trauma or neuromuscular disease. The treatment includes administering to the individual an effective amount of a metalloporphyrin compound, especially hemin, heme arginate, cobalt protoporphyrin IX chloride and cobalt protoporphyrin IX arginate.
REFERENCES:
Sadeh, Menachem et al., Journal of the Neurological Sciences (1985) 67:229-238.
Funanage, V., et al., Abstract: "Hemin Enhances Regeneration of Bipuvacaine-Damaged Rat Skeletal Muscle" American Pediatric Society Meeting, May 7-10, 1990.
Cintins Marianne M.
Lew Jeffrey C.
MacMillan Keith
The Nemours Foundation
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