Method of treating fibrosis in skeletal muscle tissue

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514502, 514492, 514493, 514494, 514495, 514498, 514499, 514501, 514505, A61K 3816, A61K 31295

Patent

active

056041993

ABSTRACT:
A method of treating skeletal muscle fibrosis in mammals. The novel method is effective for reducing the extent of skeletal muscle fibrosis in an individual who suffers from a disorder which targets skeletal muscle tissue, such as Duchenne's and Becker's muscular dystrophy and denervation atrophy induced by either trauma or neuromuscular disease. The treatment includes administering to the individual an effective amount of a metalloporphyrin compound, especially hemin, heme arginate, cobalt protoporphyrin IX chloride and cobalt protoporphyrin IX arginate.

REFERENCES:
Sadeh, Menachem et al., Journal of the Neurological Sciences (1985) 67:229-238.
Funanage, V., et al., Abstract: "Hemin Enhances Regeneration of Bipuvacaine-Damaged Rat Skeletal Muscle" American Pediatric Society Meeting, May 7-10, 1990.

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