Murine hybridoma 4A11 and diagnostic antibody produced thereby

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...

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5303882, 5303881, 935104, 435344, C12N 512, C07K 1628

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active

056041268

ABSTRACT:
Hybridoma 4A11 produces a murine IgM monoclonal antibody specifically against endothelial cells in diseased tissues such as rheumatoid and osteoarthritis synovial tissues, and psoriatic skin. The 4A11 antibody has possible clinical utility for detection of human endothelial cells mainly in inflamed and malignant disease states.

REFERENCES:
Koch et al, Immunolocalization . . . Tissues, Lab Invest. 64(3):313-320, 1991.
Koch et al, Monoclonal Ab . . . Selectively, Arthritis Rheum 34(9):5156, 1991.
Koch et al Monoclonal Ab . . . Selectively, Clin. Res. 39(2)180A, 1991.
Alles, et al., "Immunohistochemical and Immunochemical Characterization of a New Endothelial Cell-Specific Antigen" J. Histochem. and Cytochem. 34:209-214 (1986).
Bevilacqua, et al. I "Identification of an Inducible Endothelial-Leukocyte Adhesion Molecule" Proc. Natl. Acad. Sci. USA 84:9238-42 (1987).
Bevilacqua, et al. II "Interleukin-1 Activation of Vascular Endothelium: Effects on Procoagulant Axrivity and Leukocuye Adhesion" Am. J. Path. 121:393-403 (1985).
Bevilacqua, et al. III "Endothelial Leukocyte Adhesion Molecule 1: An Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins" Science 243:1160-65 (1989).
Butcher, et al. "Organ Specificity of Lymphocyte Migration: Mediation by Highly Selective Lymphocyte Interaction With Organ-Specific Determinants on High Endothelial Venules" Eur. J. Immunol. 10:556-561 (1980).
Carlos, et al. "Membrane Proteins Involved in Phagocyte Adherence to Endothelium" Immunol. Rev. 114:5-28 (1990).
Chin, et al. "A Monoclonal Anti-HEBG.sub.pp Antibody With Specificity For Lymphocyte Surface Molecules Mediating Adhesion to Peyer's Patch High Endothelium of the Rat" J. Immunol. 136:2556-61 (1986).
Cotran, et al. "Induction and Detection of a Human Endothelial Activation Antigen in Vivo" J. Exp. Med. 164:661-666 (1986).
Duijvestijn, et al. "Lymphoid Tissue- and Inflammation-Specific Endothelial Cell Differentiation Defined by Monoclonal Antibodies" J. Immunol. 138:713-719 (1987).
Gallatin, et al. "A Cell-Surface Molecule Involved in Organ-Specific Homing of Lymphocytes" Nature 304:30-34 (1983).
Goerdt, et al. "Characterization and Expression Kinetics of an Endothelial Cell Activation Antigen Present in vivo Only in Acute Inflammatory Tissues" Expl. Cell Biol. 55:117-126 (1987).
Hagemeier, et al. "A Monoclonal Antibody Reacting With Endothelial Cells of Budding Vessels in Tumors and Inflammatory Tissues, and Non-Reactive With Normal Adult Tissues" Int. J. Cancer 38:481-488 (1986).
Jalkanen, et al. "A Lymphoid Cell Surface Glycoprotein Involved in Endothelial Cell Recognition and Lymphocyte Homing in Man" Eur. J. Immunol. 16:1195-1202 (1986).
Munro, et al. "Tumor Necrosis Factor and Interferon- .gamma. Induce Distinct Patterns of Endothelial Activation and Associated Leukocyte Accumulation in Skin of Papio Anubis" Amer. J. Path. 135:121-33 (1989).
Pober, et al. I "Two Distinct Monokines, Interleukin 1 and Tumor Necrosis Factor, Each Independently Induce Biosynthesis and Transient Expression of the Same Antigen on the Surface of Cultured Human Vascular Endothelial Cells" J. Immunol. 136:1680-87 (1986).
Pober, et al. II "Expression of Ia-like Antigens by Human Vascular Endothelial Cells is Inducible in vitro: Demonstration by Monoclonal Antibody Binding and Immunoprecipitation" Proc. Natl. Acad. Sci. USA 79:6641-45 (1982).
Schlingemann, et al. "Monoclonal Antibody PAL-E Specific for Endothelium" Lab. Invest. 52:71-76 (1985).
Scully, et al. "AIDS-Related Kaposi's Sarcoma Displays Differential Expression of Endothelial Surface Antigens" Amer. J. Path. 130:244-251 (1988).
Koch et al, Pathobiol., 1990, 58:241, Reactivity . . . Antigens.
Furukawa et al., Mol. Immunol., 27(8):723, 1990.

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