Bis-esters of alkanediols

Details Bis-esters of alkanediols Bis-esters of alkanediols

1982-09-20

1984-10-23

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602391, 424270, 424271, C07D49900, A61K 31425

Patent

active

044787480

ABSTRACT:
6-Acylaminopenicillanoyloxymethyl esters and 1-(6-acylaminopenicillanoyloxy)ethyl esters of 2-beta-acetoxymethyl-2-alpha-methyl-(5R)penam-3-alpha-carboxylic acid 1,1-dioxide are useful as antibacterial agents. The 6-aminopenicillanoyloxymethyl ester, the 1-(6-aminopenicillanoyloxy)ethyl ester and certain other mono-substituted methyl and ethyl esters of 2-beta-acetoxymethyl-2-alpha-methyl-(5R)penam-3-alpha-carboxylic acid 1,1-dioxide are useful intermediates to the aforesaid antibacterial agents.

REFERENCES:
patent: 4234579 (1980-11-01), Barth
patent: 4244951 (1981-01-01), Bigham
patent: 4340539 (1982-07-01), Gottstein et al.
patent: 4364957 (1982-12-01), Barth
patent: 4375434 (1983-03-01), Hageman
patent: 4377524 (1983-03-01), Bigham

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