Preparation of antibiotic cryptdin peptides

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides

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530300, 530334, 530335, 5303871, 435 71, 514 2, 514 12, 514 21, 436503, 436547, 536 231, C07K 500, G01N 3353, A61K 3817

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active

060574259

ABSTRACT:
The present invention provides a method of preparing substantially purified cryptdin peptides having a consensus amino acid sequence:

REFERENCES:
patent: 4304715 (1981-12-01), Hudson et al.
patent: 4543252 (1985-09-01), Lehrer et al.
patent: 4659692 (1987-04-01), Lehrer et al.
patent: 4705777 (1987-11-01), Lehrer et al.
patent: 5032574 (1991-07-01), Wilde et al.
patent: 5191015 (1993-03-01), Sheppard et al.
patent: 5422424 (1995-06-01), Selsted et al.
patent: 5459235 (1995-10-01), Selsted et al.
patent: 5731149 (1998-03-01), Selsted et al.
patent: 5840498 (1998-11-01), Selsted et al.
patent: 5844072 (1998-12-01), Selsted et al.
patent: 5861378 (1999-01-01), Iwanaga et al.
Belcourt, R. et al., "Purification of cationic cystine-rich peptides from rat bone marrow," Regul. Pept., 40:87-100 (1992).
Yount, N.Y., et al., "cDNA and Genomic Cloning of beta-Defensin BNBD-4," Abstracts of the 94th General Meeting of the American Society for Microbiology, 94:23-27 (1994).
Campbell, "Monoclonal Antibody Technology", Elseiver Science Pub. 1-32 (1986).
Panyutoch et al., J. Immunological Methods, 141:149 (1991).
Notification of Transmittal of International Search Report for PCT/US95/13328 mailed Feb. 21, 1996.
Selsted, Michael A., "Enteric Defensins: Antibiotic Peptide Components of Intestinal Host Defense," J. Cell Biol. 118:929-936 (1992).
Maurer, P.H. and Callahan, H.J., "Proteins and Polypeptides as Antigens," Methods in Enzymology, 70:49-70 (1980).
Eisenhauer et al., "Cryptdins: Antimicrobial Defensins of the Murine Small Intestine," Infection and Immunity 60:3556-3565 (1992).
Ouellette et al., "Developmental Regulation of Cryptdin, a Corticostatin/Defensin Precursor mRNA in Mouse Small Intestinal Crypt Epithelium," J. Cell. Biol., 108:1687-1695 (1989).
Ouellette et al., "Purification and Primary Structure of Murine Cryptdin-1, a Paneth Cell Defensin," FEBS 304:146-148 (1992).
Ouellette and Lualdi, "A Novel Mouse Gene Family Coding for Cationic, Cysteine-rich Peptides," J. Biol. Chem. 265:9831-9837 (1990).
Ganz et al., "Defensins," Eur. J. Haematol., 44:1-8 (1990).
Kagan, B.L., "Amtimicrobial Defensin Peptides Form Voltage-Dependent Ion-Permeable Channels in Planar Lipid Bilayer Membranes," Proc. Natl. Acad. Sci., USA, 87:210-214 (1990).
Ouellette et al., "Localization of the Cryptdin Locus on Mouse Chromosome 8," Genomics 5:233-239 ( 1989).
Wimley et al., "Interactions Between Human Defensins and Lipid Bilayers: Evidence for Formation of Multimeric Pores," Protein Sci. 3:1362-1373 (1994).
Selsted, Michael E., "Investigational Approaches for Studying the Structures and Biological Functions of Myeloid Antimicrobial Peptides," Genetic Eng., 15:131-147 (1993).
Huttner et al., "Structure and Diversity of the Murine Cryptdin Gene Family," Genomics 19:448-453 (1994).
Ouellette et al., "Mouse Paneth Cell Defensins: Primary Structures and Antibacterial Activities of Numerous Cryptdin Isoforms," Infect. and Immun., 62:5040-5047 (1994).
Aley et al., "Killing of Giardia Lamblia by Cryptdins and Cationic Neutrophil Peptides," Infect. and Immun., 62:5397-5403 (1994).
Miller et al., "Purification and Characterization of a Secreted Paneth Cell Defensin Using phoP Mutants of Salmonella Typhimurium," ASCB/EMBO Summer Conference, Abstract (1991).
Chow, et al., "Fmoc Solid Phase Peptide Synthesis of Defensins," Proceeding of the Sixth Symposium of The Protein Society, Abstract (1992).
Talmadge, Advanced Drug Delivery Reviews, 10:247-299 (1993).

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