Cardiotonic 3-methyl-4-(4-pyridinyl)benzeneamine compositions an

Details Cardiotonic 3-methyl-4-(4-pyridinyl)benzeneamine compositions an Cardiotonic 3-methyl-4-(4-pyridinyl)benzeneamine compositions an

1982-02-08

1983-11-15

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546329, A61K 3144

Patent

active

044155786

ABSTRACT:
3-Methyl-4-(4-pyridinyl)benzeneamines, useful as cardiotonic agents, are prepared by reaction of pyridine, benzoyl chloride and an appropriate 3-methyl-N,N-di-lower-alkylbenzeneamine in the presence of copper powder and decomposing the reaction mixture with alkali and, if desired, reacting a resulting 3-methyl-4-(4-pyridinyl)-N,N-di-lower-alkylbenzeneamine with hydrogen bromide and pyridine to obtain 3-methyl-4-(4-pyridinyl)benzeneamine.

REFERENCES:
patent: 2265432 (1941-12-01), Kershaw et al.
patent: 2820039 (1958-01-01), Doub et al.
Merck Index 9th Ed. (1976) p. 7362.
Koenigs et al., Ann., 509, 142-158 (1934).
Forsythe et al., J. Chem. Soc. 2921 (1926).

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