Method and compositions for making ACSF and ACSF antagonists

Details Method and compositions for making ACSF and ACSF antagonists Method and compositions for making ACSF and ACSF antagonists

1994-10-25

1997-08-12

Jones, W. Gary

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4353201, 435358, 435325, 435364, 435367, 435365, 435369, 536 231, 536 235, 536 2351, C07H 2102, C07H 2104, C12N 510, C12P 2100

Patent

active

056564554

ABSTRACT:
The complete amino acid and nucleotide sequence for adenylate cyclase stimulating factor is provided, thereby facilitating the synthesis of ACSF in recombinant cell culture. ACSF amino acid sequence variants and ACSF antibodies are provided which are useful in the treatment of humoral hypercalcemia of malignancy or in immunoassays for ACSF. In particular, antibodies capable of binding only the C-terminal domains of ACSF are useful in immunoassays for ACSF which avoid interference by parathyroid hormone. Also provided are novel polypeptides selected from the group of the ACSF basic peptide, the ACSF C-terminal peptide, or the ACSF domain containing both of the basic and C-terminal peptides.

REFERENCES:
patent: 4703008 (1987-10-01), Lin
patent: 5116952 (1992-05-01), Martin et al.
Suva et al, Gene 77:95-105, 1989.
Vasicek et al, P.N.A.S. 80:2127-2131, 1983.
Hellerman et al, P.N.A.S. 81:5340-5344, 1984.
Suva et al, Science 237:893-896, 1987.

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