Transdermal therapeutic systems for the administration of naloxo

Details Transdermal therapeutic systems for the administration of naloxo Transdermal therapeutic systems for the administration of naloxo

1984-10-09

1986-03-04

Metz, Andrew H.

Surgery

Controlled release therapeutic device or system

Osmotic or diffusion pumped device or system

424 28, 514282, 514785, 604897, 514946, A61K 900

Patent

active

045739951

ABSTRACT:
A method for transdermal delivery of naloxone, naltrexone and nalbuphine base through intact skin is described. Preferred embodiments of transdermal therapeutic systems for delivering these drugs and polyethylene glycol monolaurate employ an ethylene vinylacetate matrix containing drug base at a concentration above saturation and polyethylene glycol monolaurate below unit activity. Polyethylene glycol manolaurate is disclosed as a permeation enhancer for the base form of these drugs and is preferably delivered simultaneously with the drug.

REFERENCES:
patent: 4141897 (1979-02-01), Olofson et al.
patent: 4201211 (1980-05-01), Chandrasekaran et al.
patent: 4435180 (1984-03-01), Leeper
patent: 4460372 (1984-07-01), Campbell et al.
patent: 4464378 (1984-08-01), Hussain
patent: 4493848 (1985-01-01), LaHann et al.

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