Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1986-03-21
1987-09-29
Ford, John M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
540582, 540477, C07D22104, C07D22314
Patent
active
046970193
ABSTRACT:
A compound of formula (XXII): ##STR1## or a compound of formula (XXIII): ##STR2## wherein in formula (XXIII), j.sup.1 -1 is 1 to 4; and Q.sub.6 and Q.sub.7 are on the same carbon atom; and wherein, in formulae (XXII) and (XXIII), Q.sub.6 is NH.sub.2 and Q.sub.7 is H, and either p is 0 to 2 and q is 1; or p is 1 and q is 0 to 3; and one of R.sub.5 and R.sub.6 is hydrogen, C.sub.1-6 alkyl, phenyl or phenyl --C.sub.1-3 alkyl, which phenyl moieties may be substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, CF.sub.3 or halogen; and the other of R.sub.5 and R.sub.6 is hydrogen or C.sub.1-6 alkyl.
REFERENCES:
patent: 4182884 (1980-01-01), Wong
patent: 4336259 (1982-06-01), Hadley et al.
Chizhov et al., Chem. Abstracts, vol. 53, p. 21958e, (1959).
O. Oldenziel, D. van Leusen, and A. van Leusen, "A General One-Step Synthesis of Nitriles from Ketones Using Tosylmethyl Isocyanide, Introduction of a One Carbon Unit," J. Org. Chem., 42, pp. 3114-3118, (1977).
P. Protais, J. Costentin and J. C. Schwartz, "Climbing Behavior Induced by Apomorphine in Mice, A Simple Test for the Study of Dopamine Receptors in Striatum," Psychopharmacology, 50, pp. 1-6, (1976).
Beecham Group p.l.c.
Brady, Jr. James W.
Ford John M.
Haley, Jr. James F.
Richter J.
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