Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Para-n-benzene - sulfoxy-n containing doai – and said benzene...
Patent
1983-11-07
1987-09-29
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Para-n-benzene - sulfoxy-n containing doai, and said benzene...
514272, 514314, A61K 31635, A61K 31505, A61K 3147
Patent
active
046969217
ABSTRACT:
Mixtures of active substances and pharmaceutical compositions useful in malaria therapy comprising a quinolinemethanol derivative of the formula ##STR1## wherein R.sup.1 is hydrogen, fluorine, chlorine, bromine, methyl or trifluoromethyl, R.sup.2 is hydrogen, fluorine, chlorine, bromine, methyl or methoxy (at least one of R.sup.1 and R.sup.2 is other than hydrogen), and R.sup.3 is C.sub.1-6 -alkylamino-C.sub.1-3 -alkyl, di-C.sub.1-6 -alkylamino-C.sub.1-3 -alkyl, 2-piperidyl or 3-piperidyl, or a pharmaceutically acceptable acid addition salt thereof; a compound which acts as a p-aminobenzoic acid antagonist; and a compound which acts as a dihydrofolic acid reductase inhibitor, are described.
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Ohnmacht et al., J. Med. Chem., 14, pp. 926-928, (1971).
Peters, Bull. World Health Organ., 51, pp. 379-383, (1974).
Otten et al., Antibiotika Fibel, 4th Ed., 1975, pp. 953-961.
J. Med. Chem., 18, pp. 1122-1126, (1975).
Merkli et al., Acta Tropica, 37, 228-231, (1980).
Clinical Pharmacology and Therapeutics, 10 (1969), pp. 85-91.
A. P. Hall: British Medical Journal, 1 (1976), pp. 323-328.
T. R. Sweeney, Medical Research Reviews, 1 (1981), pp. 281-301.
Boxer Matthew
Goldberg Jerome D.
Hoffmann-La Roche Inc.
Leon Bernard S.
Saxe Jon S.
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