Nuclease-resistant hydrophilic complex of polyriboinosinic-polyr

Details Nuclease-resistant hydrophilic complex of polyriboinosinic-polyr Nuclease-resistant hydrophilic complex of polyriboinosinic-polyr

1974-09-27

1976-04-20

Gotts, Lewis

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, 2602115R, 260231CM, 424180, 424361, 424362, A61K 3700, C07C10352, C07H 1900

Patent

active

039520978

ABSTRACT:
A nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid, poly-1-lysine and carboxymethylcellulose, and injectable preparations thereof in a pharmaceutically acceptable aqueous carrier such as saline solution. When administered to a non-human primate host, the complex is effective in inducing the synthesis in such host of antiviral levels of interferon.

REFERENCES:
patent: 2851453 (1958-09-01), Kennon
patent: 3066075 (1962-11-01), Deutsch
patent: 3493559 (1970-03-01), Hunter
patent: 3821193 (1974-06-01), Fare et al.
patent: 3843629 (1974-10-01), Sheit et al.
patent: 3845033 (1974-10-01), Harnden
patent: 3853846 (1974-12-01), Prasad et al.
Matsuo et al.: Bull. Chem. Soc. Japan, 39, 347-352, (1966).
Bretscher: Chem. Abstr., 60:8261h (1964).

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