Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1989-03-31
1992-04-21
Moezie, F. T.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530402, 530403, 530404, 530405, 5303917, C07K 1700
Patent
active
051069512
ABSTRACT:
There is disclosed an antibody and antibody-drug conjugate for targeting drug delivery as well as a class of chemicals, termed a drug-binding molecule of complementary structure (csDBM). The csDBM is designed to "fit" the drug by combining multiple non-covalent interactions between functional groups on the drug and opposing functional groups on the csDBM. The net result on the antibody-csDBM-drug conjugate is a drug stably bound to the csDBM so as not to dissociate during in vivo administration, but not so tightly bound to allow drug dissociation from the conjugate without significant loss of activity and retaining the drug's ability to bind to a higher affinity site on or within the target cell.
REFERENCES:
patent: 3867423 (1975-02-01), Crabbe
patent: 4472500 (1984-09-01), Milstein et al.
patent: 4474893 (1984-10-01), Reading
patent: 4507234 (1985-03-01), Kato et al.
patent: 4534971 (1985-08-01), Fisher
patent: 4642335 (1987-02-01), Miyashiro et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4689311 (1987-08-01), Weltman
patent: 4698420 (1987-10-01), Urnovitz
Hamilton et al., J. Am. Chem. Soc., vol. 109, pp. 5035-5036 (1987).
Chang et al., J. Am. Chem. Soc., vol. 110, pp. 1318-1319 (1988).
Hamilton et al., J. Am. Chem. Soc., vol. 108, pp. 5158-5167 (1986).
Hamilton et al., Tetrahed. Lett., vol. 26, pp. 5735-5738 (1985).
Mann et al., J. Chem. Soc. Chem. Commun., vol. 2, pp. 158-160 (1986).
Hamilton et al., J. Chem. Soc., Chem. Commun., vol. 5, pp. 311-313 (1984).
Rebek et al., J. Am. Chem. Soc., vol. 109, pp. 5033-5035 (1987).
Rebek, Science, vol. 235, pp. 1478-1484 (1987).
Dalmarle et al., Molecular Pharmacology, vol. 22, pp. 158-165 (1982).
Pant et al., J. Am. Chem. Soc., vol. 110, pp. 2002-2003 (1988).
Pant et al., J. Incl. Phen., vol. 5, pp. 109-111 (1987).
Larkins et al., Tetrahed. Lett., vol. 27, pp. 2721-2724 (1986).
Kelly et al., Int. J. Peptide Protein Res. 26:400-406 (1985), "DNA-Binding Compounds-Synthesis and Intercalating Properties of a Peptide-Diamino Diacridine".
Anderson David C.
Fritzberg Alan R.
Morgan, Jr. Alton C.
Reno John M.
Srinivasan Ananthachari
Moezie F. T.
NeoRx Corporation
Rozycki Andrew G.
LandOfFree
Antibody conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibody conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibody conjugates will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1587578