2-Amino-4,5-dihydropyridine derivatives and process for their pr

Details 2-Amino-4,5-dihydropyridine derivatives and process for their pr 2-Amino-4,5-dihydropyridine derivatives and process for their pr

1974-03-22

1976-04-20

Randolph, John D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260283S, 260287R, 2602948D, 2602948F, 2602949, 2602955R, C07D21332

Patent

active

039519937

ABSTRACT:
2-Amino-4,5-dihydropyridines-3,5-dicarboxylates substituted by lower alkoxy or lower alkylthio in the 6-position and optionally substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-amino-4-(3-nitrophenyl)-6-ethoxy-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester is a representative embodiment, are prepared through condensation of an aldehyde and a 3-aminoacrylate bearing an alkoxy or alkylthio group in the 3-position.

REFERENCES:
patent: 3876646 (1975-04-01), Meyer et al.
Klingsberg, Pyridine and Its Derivatives, Part Three, pp. 179 and 181, Interscience Publishers Inc. (1962).
Gewald, Chem. Ber. Vol. 101, pp. 383-390, (1968).
Chemical Abstracts, Vol. 79, Abst. No. 146402k, (1973).

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