Use of aryl- and heteroaryl piperazinyl carboxamides in the trea

Details Use of aryl- and heteroaryl piperazinyl carboxamides in the trea Use of aryl- and heteroaryl piperazinyl carboxamides in the trea

1991-04-22

1992-04-21

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514252, 514253, A61K 3150, A61K 31495

Patent

active

051068494

ABSTRACT:
There are disclosed the use of the compounds of the formula (I) ##STR1## wherein R.sup.1 is 1-adamantyl, 3-methyl-1-adamantyl, 3-noradamantyl, unsubstituted or substituted-2-indolyl, 3-indolyl, 2-benzofuranyl or 3-benzofuranyl wherein the substituents are selected from lower alkyl, lower alkoxy and halo; R.sup.2 is unsubstituted or substituted phenyl, benzyl, or pyrimidinyl wherein the substituents are selected from lower alkyl, lower alkoxy, trifluoromethyl and halo; R.sup.3 is H or lower alkyl of 1 to 3 carbon atoms; n is the integer 0 or 1; and m is the integer from 2 to 5 and the pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 4818756 (1989-04-01), Seidel et al.
patent: 4873331 (1989-10-01), Childers et al.
patent: 4880930 (1989-11-01), New
patent: 4895848 (1990-01-01), Traber

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