Linear free-sulfhydryl-containing oligopeptide derivatives as an

Details Linear free-sulfhydryl-containing oligopeptide derivatives as an Linear free-sulfhydryl-containing oligopeptide derivatives as an

1988-12-27

1992-04-21

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 530328, 530327, 530326, A61K 3702, C07K 706

Patent

active

051068346

ABSTRACT:
Synthesis and use of novel oligopeptides are described, many of which peptides contain one or several unnatural amino acids. These short linear peptide derivatives are characterized by the presence of a free sulfhydryl function. These compounds have a high affinity for the Atrial Natriuretic Peptide (ANP) receptor coupled to particulate guanylate cyclase. Such peptides are full agonists at the ANP receptor as demonstrated by the ability of the peptides to stimulate the production of cGMP and to relax smooth muscles in vitro. In accord with these observations, the compounds of the invention lower blood pressure in mammals. Preferred peptides are the following:

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