Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1994-05-03
1997-08-12
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424486, 424487, 424488, 424489, 5147723, 5147726, 514781, 514805, 514965, A61K 914, A61K 916
Patent
active
056562977
ABSTRACT:
The present invention relates to a composition for the modulated release of a biologically active agent. The composition comprises a biocompatible polymeric matrix, a biologically active agent which is dispersed within the polymeric matrix, and a metal cation component which is separately dispersed within the polymeric matrix, whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix. The present invention also relates to a method for modulating the release of a biologically active agent from a biocompatible polymeric matrix, comprising the steps of dissolving a biocompatible polymer in a solvent to form a polymer solution and also separately dispersing a metal cation component and a biologically active agent within the polymer solution. The polymer solution is then solidified to form a polymeric matrix, wherein at least a significant portion of the metal cation component is dispersed in the polymeric matrix separately from the biologically active protein, and whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix.
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Bernstein Howard
Khan M. Amin
Tracy Mark A.
Zhang Yan
Alkermes Controlled Therapeutics, Incorporated
Page Thurman K.
Spear James M.
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