Cyclic hexapeptide somatostatin analogs

Details Cyclic hexapeptide somatostatin analogs Cyclic hexapeptide somatostatin analogs

1983-08-15

1984-12-04

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125S, A61K 3700, C07C10352

Patent

active

044864159

ABSTRACT:
Somatostatin analogs are prepared wherein a cyclic hexapeptide contains a secondary amino acid which replaces seven of the ring amino acids of somatostatin. The cyclic hexapeptides are easier to synthesize, have a longer duration of activity, and many have a greater level of activity than somatostatin. The compounds have the properties of inhibiting the release of glucagon, growth hormone and insulin. Certain of the compounds also are capable of inhibiting gastric acid secretions. The compounds are particularly useful in the treatment of acromegaly, diabetes, diabetic retinopathy and peptic ulcers. These cyclic hexapeptides are prepared by the solid phase method.

REFERENCES:
patent: 4235886 (1980-11-01), Freidinger et al.
patent: 4310518 (1982-01-01), Freidinger et al.
Freidinger et al., Peptides: Structure and Function-Proceedings of the Eighth American Peptide Symposium edited by V. J. Hruby and D. H. Rich, pp. 349-352 (1983).

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