Urea-linked immunogens, antibodies, and preparative method

Details Urea-linked immunogens, antibodies, and preparative method Urea-linked immunogens, antibodies, and preparative method

1983-03-28

1984-12-04

Kight, John

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112R, 260112B, 424 85, 424 88, 424177, A61K 3704, A61K 3900

Patent

active

044863446

ABSTRACT:
Immunogen conjugates comprising amino-functionalized haptens coupled through a carbonyl bridge to amino groups in immunogenic proteins and polypeptides. The resulting simple urea linkage in the conjugate is hydrophilic and contributes essentially no haptenic determinants. The immunogen is characterized by a high epitopic density. The method involves reaction of the hapten with a carbonyl diimidazole followed by addition of the protein or polypeptide carrier. Protein crosslinking problems common to prior art coupling methods are avoided.

REFERENCES:
patent: 4041076 (1977-08-01), Avenia et al.
patent: 4192799 (1980-03-01), Fitzpatrick
patent: 4218436 (1980-08-01), Fitzpatrick
patent: 4276206 (1981-06-01), Katz
Vunakis et al., Methods in Enzymology, vol. 70, "Immunochemical Techniques", 1980, Academic Press, New York, pp. 85-103.

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