Hydroxamic acid derivatives and method of using same

Details Hydroxamic acid derivatives and method of using same Hydroxamic acid derivatives and method of using same

1988-03-14

1989-12-26

Evans, J. E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

562622, C07C 8310, A61K 73185

Patent

active

048898740

ABSTRACT:
In accordance with the present invention, new hydroxamic acid derivatives useful as .DELTA..sup.5 -lipoxygenase inhibitors are provided. These new compounds have the general formula ##STR1## wherein ##STR2## are cycloalkyl groups which may be the same or different; R is hydrogen, lower alkyl, aryl, lower alkenyl, cycloalkyl or aralkyl; n is an integer from 3 to 12; and m is an integer from 3 to 12. Further in accordance with the present invention, a method for using the above compounds is provided.

REFERENCES:
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patent: 3544583 (1970-12-01), Burk et al.
patent: 3560519 (1971-02-01), Burk, Jr. et al.
patent: 3697588 (1972-10-01), Vincent et al.
patent: 3746751 (1973-07-01), Noguchi et al.
patent: 3857946 (1974-12-01), Shibata
patent: 3900514 (1975-08-01), Chappelow et al.
patent: 3936494 (1976-02-01), Lipowski
Fieser et al, "Organic Chemistry", 3rd ed. (1956) pp. 97 and 98.

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