Substituted pyranone inhibitors of cholesterol synthesis

Details Substituted pyranone inhibitors of cholesterol synthesis Substituted pyranone inhibitors of cholesterol synthesis

1982-06-10

1984-07-10

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 60, 562470, 562469, 424308, 424310, C07C 6976

Patent

active

044594224

ABSTRACT:
6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

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patent: 3983140 (1976-09-01), Endo et al.
patent: 4198425 (1980-04-01), Mitsui et al.
patent: 4248889 (1981-02-01), Oka et al.
Brown et al., J. Chem. Soc., Perkin I, (1976), 1165-1169.
Hulcher, Arch. Biochem & Biophys, 146, 422-427, (1971).
Singer et al., Proc. Soc. Exper. Biol. Med. 102, 370-373, (1959).
Meyer, Liebigs Ann. Chem., (1979), pp. 484-491.

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