Triazolo benzodiazepine-1-carboxamides

Details Triazolo benzodiazepine-1-carboxamides Triazolo benzodiazepine-1-carboxamides

1973-11-21

1976-04-06

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239BD, 2602472A, 260268TR, 26029359, 260561H, 424250, 424267, 424269, C07D48704

Patent

active

039489310

ABSTRACT:
Compounds of the class of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxamides, their 5-oxides and their pharmaceutically acceptable acid addition salts have valuable pharmacological properties and are active ingredients for therapeutic compositions. In particular, these new compounds have an anti-convulsive and anti-aggressive action and potentiate the action of anaesthetics. Specific embodiments are N,N-dimethyl-6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-c arboxamide, 6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxamide, N,N-dimethyl-6-(o-chlorophenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiaz epine-1-carboxamide and 6-(o-chlorophenyl)-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carb oxamide.

REFERENCES:
patent: 3562251 (1971-02-01), Fryer et al.
patent: 3701782 (1972-10-01), Hester
patent: 3759943 (1973-09-01), Hester

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